The Lowy Medical Research Institute is dedicated to preventing vision loss in people with Macular Telangiectasia type 2 (MacTel). LMRI investigators work collaboratively to study possible causes of MacTel, to develop new therapies, and to bring those therapies to patients. Through the MacTel Project, LMRI connects patients with clinicians and researchers to speed the pace of discovery and keep patients informed of opportunities to participate in clinical trials.
The Lowy Medical Research Institute (LMRI) is a private, non-profit research organization dedicated to the study of Macular Telangiectasia type 2, or MacTel. The Lowy Medical Research Institute was established in 2005 to act as the parent organization and funding agency of the MacTel Project, which was initiated the same year.
When the MacTel Project started, MacTel was thought to be a disease of blood vessels in the retina. By carefully studying a group of individuals with MacTel over a period of ten years, and through extensive laboratory research, the MacTel Project has reshaped how clinicians and researchers think about the disease.
MacTel is now understood to be, first and foremost, a disease that affects the neurons in the eye. Changes in the retinal blood vessels probably do not cause the disease. Many other cells in the retina are also affected by MacTel. LMRI scientists are still working to understand the cause of the disease and the cascade of events that leads to vision loss.
The goal of LMRI’s laboratory and genetic studies is to identify and test potential new treatments. Clinicians, geneticists, vision research scientists, and retinal imaging specialists from more than 30 centers across North America, Europe, Australia, and the Middle East are involved in the MacTel Project.
To accelerate the pace of discovery, The Lowy Medical Research Institute opened a dedicated laboratory and office space in 2013, which serves as the LMRI headquarters. The facility is located on the Torrey Pines Mesa in La Jolla, California, home to the region’s vibrant and innovative life sciences community.
The MacTel Project continues to be a program of The Lowy Medical Research Institute. LMRI also supports clinical trials, in partnership with Neurotech, which is sponsoring Phase 1 and 2 clinical trials to test a therapy for Macular Telangiectasia type 2. LMRI’s clinical and laboratory research programs continues to advance knowledge about MacTel. The research programs includes an international group of collaborators, as well as an in-house scientific research staff. The goal of the research program is to understand the basis of the disease so that LMRI may identify additional therapies to effectively treat, or cure, MacTel.
Not For Profit Status
The Institute’s not-for-profit charter is embedded within its constitution:
“The assets and income of the Institute shall be applied solely in furtherance of the objectives [to be a public institution engaged solely in research into the causes, prevention or cure of disease in human beings] of the Institute and no portion of the income or assets of the Institute may be paid or transferred, directly or indirectly to any Member, except as bona fide compensation for services rendered or expenses incurred on behalf of the Institute.”
The Institute is a registered health promotion charity in Australia, registered with the Australian Government’s Charities and not-for-profits Commission.
Clinical Research and Trials – Overhead Contribution Policy
The Institute has a policy of paying no more than a 20% overhead rate in respect of research partners’ indirect costs.