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Overview

Mission Statement

The Lowy Medical Research Institute is dedicated to preventing vision loss in people with Macular Telangiectasia type 2 (MacTel). LMRI investigators work collaboratively to study possible causes of MacTel, to develop new therapies, and to bring those therapies to patients. Through the MacTel Project, LMRI connects patients with clinicians and researchers to speed the pace of discovery and keep patients informed of opportunities to participate in clinical trials.

History

The Lowy Medical Research Institute (LMRI) is a private, non-profit research organization dedicated to the study of Macular Telangiectasia type 2, or MacTel. The Lowy Medical Research Institute was established in 2005 to act as the parent organization and funding agency of the MacTel Project, which was initiated the same year.

When the MacTel Project started, MacTel was thought to be a disease of blood vessels in the retina. By carefully studying a group of individuals with MacTel over a period of ten years, and through extensive laboratory research, the MacTel Project has reshaped how clinicians and researchers think about the disease.

MacTel is now understood to be, first and foremost, a disease that affects the neurons in the eye. Changes in the retinal blood vessels probably do not cause the disease. Many other cells in the retina are also affected by MacTel. LMRI scientists are still working to understand the cause of the disease and the cascade of events that leads to vision loss.

The goal of LMRI’s laboratory and genetic studies is to identify and test potential new treatments. Clinicians, geneticists, vision research scientists, and retinal imaging specialists from more than 30 centers across North America, Europe, Australia, and the Middle East are involved in the MacTel Project.

To accelerate the pace of discovery, The Lowy Medical Research Institute opened a dedicated laboratory and office space in 2013, which serves as the LMRI headquarters. The facility is located on the Torrey Pines Mesa in La Jolla, California, home to the region’s vibrant and innovative life sciences community.

The MacTel Project continues to be a program of The Lowy Medical Research Institute. LMRI also supports clinical trials, in partnership with Neurotech, which is sponsoring Phase 1 and 2 clinical trials to test a therapy for Macular Telangiectasia type 2. LMRI’s clinical and laboratory research programs continues to advance knowledge about MacTel. The research programs includes an international group of collaborators, as well as an in-house scientific research staff. The goal of the research program is to understand the basis of the disease so that LMRI may identify additional therapies to effectively treat, or cure, MacTel.

Not For Profit Status

The Institute’s not-for-profit charter is embedded within its constitution:

“The assets and income of the Institute shall be applied solely in furtherance of the objectives [to be a public institution engaged solely in research into the causes, prevention or cure of disease in human beings] of the Institute and no portion of the income or assets of the Institute may be paid or transferred, directly or indirectly to any Member, except as bona fide compensation for services rendered or expenses incurred on behalf of the Institute.”

The Institute is a registered health promotion charity in Australia, registered with the Australian Government’s Charities and not-for-profits Commission.

Clinical Research and Trials – Overhead Contribution Policy

The Institute has a policy of paying no more than a 20% overhead rate in respect of research partners’ indirect costs.

United Kingdom

Moorfields Eye Hospital
London, United Kingdom
Cathy Egan, MD
011 44 20 7566 2262
catherine.egan@moorfields.nhs.uk

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United States

California

Scripps Research Institute
La Jolla, CA USA
Martin Friedlander, MD, PhD
858-784-9138
friedlan@scripps.edu

Jules Stein Eye Institute, UCLA
Los Angeles, CA USA
Jean-Pierre Hubschman, MD
310-206-5004
hubschman@jsei.ucla.edu

Florida

Bascom Palmer Eye Institute, University of Miami
Miami, FL USA
Philip Rosenfeld, MD
305-326-6538
prosenfeld@med.miami.edu

Massachusetts

Massachusetts Eye and Ear Infirmary
Boston, MA USA
Joan Miller, MD
617-578-3257
joan.miller@meei.harvard.edu

Michigan

University of Michigan, Kellogg Eye Center
Ann Arbor, MI USA
Grant Comer, MD
734-763-5906
gcomer@umich.edu

New York

Manhattan Eye, Ear & Throat Hospital
New York, NY USA
Michael Cooney, MD
212 861-9797
m.cooney@vrmny.com

The New York Eye and Ear Infirmary
New York, NY USA
Richard Rosen, MD
212-979-4284
rrosen@nyee.edu

Ohio

Retina Associates of Cleveland, Inc.
Cleveland, OH USA
Lawrence Singerman, MD
216-831-5700
lsingerman@retina-assoc.com

Pennsylvania

Scheie Eye Institute
Philadelphia, PA USA
Alexander Brucker, MD
215-662-8675
ajbrucke@mail.med.upenn.edu

Utah

University of Utah Medical Center
Salt Lake City, Utah
Paul Bernstein, MD, PhD.
801-581-6078
paul.bernstein@hsc.utah.edu

Virginia

The Retina Group of Washington
Fairfax, VA USA
Robert Murphy, MD
703-698-9335
rpmurphy@comcast.net

Wisconsin

University of Wisconsin
Madison, WI USA
Barbara Blodi, MD
608-263-6646
bablodi@wisc.edu

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France

Hopital Lariboisiere
Paris, France
Alain Gaudric, MD
011 33 1 4995 2475
alain.gaudric@lrb.aphp.fr

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Germany

Universitats-Augenklinik Bonn
Bonn, Germany
Frank Holz, MD
011 49 228 287 5647
Frank.Holz@ukb.uni-bonn.de

St. Franziskus Hospital
Muenster, Germany
Prof. Daniel Pauleikhoff
dapauleikhoff@muenster.de
Bjorn Padge, MD
011 49-251-93308-0
bjoern@padge.de

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Israel

The Goldschleger Eye Institute
Tel Hashomer, Israel
Joseph Moisseiev, MD
011 972 3 5343462
Joseph.moisseiev@sheba.health.gov.il

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Switzerland

Klinik und Poliklinik fur Augenheilkunde
Inselspita
University of Bern
Bern, Switzerland
Sebastian Wolf, MD, PhD
41 31 6328503
sebastian.wolf@insel.ch

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Australia

Center for Eye Research Australia
Melbourne, Australia
Robyn Guymer, MD
011 61 3 9929 8393
rhg@unimelb.edu.au

Lions Eye Institute
Nedlands, Australia
Ian Constable, MD
011 61 8 9381 0882
ijc@cyllene.uwa.edu.au

Save Sight Institute
Sydney NSW Australia
Mark Gillies, MD, PhD
011 61 412 060 313
mark.gillies@sydney.edu.au

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