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Overview

Mission Statement

The Lowy Medical Research Institute is dedicated to preventing vision loss in people with Macular Telangiectasia type 2 (MacTel). LMRI investigators work collaboratively to study possible causes of MacTel, to develop new therapies, and to bring those therapies to patients. Through the MacTel Project, LMRI connects patients with clinicians and researchers to speed the pace of discovery and keep patients informed of opportunities to participate in clinical trials.

History

The Lowy Medical Research Institute (LMRI) is a private, non-profit research organization dedicated to the study of Macular Telangiectasia type 2, or MacTel. The Lowy Medical Research Institute was established in 2005 to act as the parent organization and funding agency of the MacTel Project, which was initiated the same year.

When the MacTel Project started, MacTel was thought to be a disease of blood vessels in the retina. By carefully studying a group of individuals with MacTel over a period of ten years, and through extensive laboratory research, the MacTel Project has reshaped how clinicians and researchers think about the disease.

MacTel is now understood to be, first and foremost, a disease that affects the neurons in the eye. Changes in the retinal blood vessels probably do not cause the disease. Many other cells in the retina are also affected by MacTel. LMRI scientists are still working to understand the cause of the disease and the cascade of events that leads to vision loss.

The goal of LMRI’s laboratory and genetic studies is to identify and test potential new treatments. Clinicians, geneticists, vision research scientists, and retinal imaging specialists from more than 30 centers across North America, Europe, Australia, and the Middle East are involved in the MacTel Project.

To accelerate the pace of discovery, The Lowy Medical Research Institute opened a dedicated laboratory and office space in 2013, which serves as the LMRI headquarters. The facility is located on the Torrey Pines Mesa in La Jolla, California, home to the region’s vibrant and innovative life sciences community.

The MacTel Project continues to be a program of The Lowy Medical Research Institute. LMRI also supports clinical trials, in partnership with Neurotech, which is sponsoring Phase 1 and 2 clinical trials to test a therapy for Macular Telangiectasia type 2. LMRI’s clinical and laboratory research programs continues to advance knowledge about MacTel. The research programs includes an international group of collaborators, as well as an in-house scientific research staff. The goal of the research program is to understand the basis of the disease so that LMRI may identify additional therapies to effectively treat, or cure, MacTel.

Not For Profit Status

The Institute’s not-for-profit charter is embedded within its constitution:

“The assets and income of the Institute shall be applied solely in furtherance of the objectives [to be a public institution engaged solely in research into the causes, prevention or cure of disease in human beings] of the Institute and no portion of the income or assets of the Institute may be paid or transferred, directly or indirectly to any Member, except as bona fide compensation for services rendered or expenses incurred on behalf of the Institute.”

The Institute is a registered health promotion charity in Australia, registered with the Australian Government’s Charities and not-for-profits Commission.

Clinical Research and Trials – Overhead Contribution Policy

The Institute has a policy of paying no more than a 20% overhead rate in respect of research partners’ indirect costs.

United Kingdom
Moorfields Eye Hospital

London, United Kingdom
Cathy Egan, MD

Emily Magnus
Tel: 020 7566 2117
Email:Emily.Magnus@moorfields.nhs.uk
 

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United States

California

Scripps Research Institute

La Jolla, CA USA
Martin Friedlander, MD, PhD

Jennifer Trombley, RN
Tel: 858-554-6678
Email: Trombley.jennifer@scrippshealth.org

Jules Stein Eye Institute, UCLA

Los Angeles, CA USA
Jean-Pierre Hubschman, MD

Veronika Sadykov
Tel: 310-794-5596
Email: Sadykov@jsei.ucla.edu

Mary Crowley
Tel: 310-267-5278 Email:
Email: MECrowley@mednet.ucla.edu

University of California – San Francisco

UCSF Department of Ophthalmology
San Fransciso, CA USA
Jacque Duncan, MD

Arshia Mian
Tel: 415-476-0444
Email: arshia.mian@ucsf.edu

Florida

Bascom Palmer Eye Institute, University of Miami

Miami, FL USA
Philip Rosenfeld, MD

Cristina Lage-Rodriguez
Tel: 305-326-6117
Email: clage@med.miami.edu

Georgia

Emory University

Atlanta, GA
Jiong Yan, MD

Jayne Brown
Tel: 404-778-4430
Email: jmbrown@emory.edu

Louisiana

Retina Associates New Orleans

New Orleans, LA USA
Stanislav A. Zhuk, MD

Corey Marvel
Tel: 504-456-9061 ext 1111
Email: cmarvel@retinaassociates.org

Melinda Mitchell
Email: Melinda.mitchell@retinaassociates.org

Massachusetts

Massachusetts Eye and Ear Infirmary

Boston, MA USA
Joan Miller, MD

Patricia Houlihan
Tel: 617-573-3646
Email: patricia_houlihan@meei.harvard.edu

Michigan

University of Michigan, Kellogg Eye Center

Ann Arbor, MI USA
Grant Comer, MD

Pam Campbell
Tel: 734-936-0138
Email: pamtitus@med.umich.edu

New York

Vitreous, Retina, Macula Consultants of New York

New York, NY USA
Lawrence A. Yannuzzi, MD

Renata Salgado
Tel: 212-452-6965
Email: rsalgado@vrmny.com

The New York Eye and Ear Infirmary

New York, NY USA
Richard Rosen, MD

Meliza Unson
Tel: 212-979-4672
Email: munson@nyee.edu

University of Rochester

Rochester, NY USA
Mina Chung, MD

Lisa Latchney
Tel: 585-273-2742
Email: Lisa_latchney@urmc.rochester.edu

Ohio

Retina Associates of Cleveland, Inc.

Cleveland, OH USA
Lawrence Singerman, MD

Diane Weiss
Tel: 216-831-5704 Ext. 244
Email: dew@retina-assoc.com

Cincinnati Eye Institute

Cincinnati, OH USA
Daniel Miller, MD

Megan Kingdon
Tel: 513-569-3669
Email: mkingdon@cincinnatieye.com

Pennsylvania

Scheie Eye Institute

Philadelphia, PA USA
Alexander Brucker, MD

Sheri Drossner
Tel: 215-662-8177
Email: Sheri.Grand@uphs.upenn.edu

Texas

Retina Research Center

Austin, TX USA
Chirag Jhaveri, MD
Brian Berger, MD

Ivana Gunderson
Tel: 512-279-1251
Email: igunderson@e-retina.net

Utah

University of Utah Medical Center

Salt Lake City, Utah
Paul Bernstein, MD, PhD.

Kara Halsey
Tel: 801-213-2034
Email: Kara.halsey@utah.edu

Virginia

The Retina Group of Washington

Fairfax, VA USA
Robert Murphy, MD

Irene Fanous
Tel: 703-564-7519
Email: ifanous@rgw.com

Wisconsin

Medical College of Wisconsin

Milwaukee, WI USA
David Weinberg, MD

Ellie Dorsey
Tel: 414-955-7854
Email: edorsey@mcw.edu
 

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France
Hopital Lariboisiere

Paris, France
Alain Gaudric, MD

Abir Zureik
Tel: 33 1 49 95 64 86
Email: abir.zureik@aphp.fr
 

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Germany
Universitats-Augenklinik Bonn

Bonn, Germany
Frank Holz, MD

Simone Müller
Email: Simone.Mueller@ukbonn.de

Kerstin Bartsch
Email: Kerstin.Bartsch@ukbonn.de

St. Franziskus Hospital

Muenster, Germany
Prof. Daniel Pauleikhoff

Elke Attenberger
Tel: 0251-9352758
Email: elke.attenberger@uveitis-zentrum.de
 

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Israel
The Goldschleger Eye Institute

Tel Hashomer, Israel
Joseph Moisseiev, MD

Rinat Rashty
Tel: 972-3-530 2877
Email: Rinat.rashty@sheba.health.gov.il

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Switzerland

Klinik und Poliklinik fur Augenheilkunde
Inselspita
University of Bern
Bern, Switzerland
Sebastian Wolf, MD, PhD
41 31 6328503
sebastian.wolf@insel.ch

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Australia
Center for Eye Research Australia

Melbourne, Australia
Robyn Guymer, MD

Melinda Cain
Tel: 61 3 9929 8396
Email: mcain@unimelb.edu.au

Emily Caruso
Tel: 61 3 9929 8113
Email: emily.caruso@unimelb.edu.au

Lions Eye Institute

Nedlands, Australia
Ian Constable, MD

Toni Busby
Tel: +61 08 6382 0582
Email: toni.busby@lei.org.au

Diana Bowman
Tel: +61 8 9381 0777
Email: DianaBowman@lei.org.au

Save Sight Institute

Sydney NSW Australia
Mark Gillies, MD, PhD

Antoinette Dezoysa
Tel +61 2 9382 7309
Email: Antoinette.dezoysa@sydney.edu.au

Sharon McKenzie
Tel +61 2 9382 7309
Email: sharon.mckenzie@sydney.edu.au

 
 

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Netherlands
Radboud University Medical Center

Nijmegen, Netherlands

CB Hoyng, MD
Tel: +31 (0)24 36 15255
Email: trialcentrum.ohk@radboudumc.nl

Asha Kalisingh
Tel: + 0243613212
Email: asha.kalisingh@radboudumc.nl
 

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