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The Value of Basic and Translational Research

basic research
The study of mitochondria, shown here in this electron micrograph, could lead to important clues about MacTel.

Basic research is the foundation of medical discovery.  Through it, we learn key information about the fundamental biological, molecular, and chemical processes of life.

Translational research is the process of taking a discovery from the laboratory into the clinic, where it can ultimately help people.  Often referred to as “bench to bedside” research, it encompasses several stages.  These include testing hypotheses using disease models in the laboratory, bringing new therapies to the clinic to determine their effectiveness in patients, and evaluating if new therapies lead to improved public health.

The mission of the Lowy Medical Research Institute is to improve the lives of people affected by MacTel by developing new therapies to treat or cure MacTel.  Realizing that mission requires us to engage in both basic and translational research.  LMRI supports basic research to learn more about the fundamental biology behind changes that occur in a MacTel eye.  LMRI also supports translational research, from preclinical studies to clinical trials.

At the Lowy Medical Research Institute, basic and translational research are tightly interconnected.  All of the basic science LMRI supports is directly related to MacTel.  The LMRI researchers who do basic research also have ongoing translational research projects.  Open lines of communication between scientists and clinicians speed the pace of discovery and translation to the clinic.

The LMRI research program is designed to help people with MacTel.  However, its discoveries will reach beyond the MacTel community.  The basic research program contributes to the fundamental knowledge of the eye, and could lead to new therapies or new ways of thinking about other forms of vision disease.

 

United Kingdom

Moorfields Eye Hospital
London, United Kingdom
Cathy Egan, MD
011 44 20 7566 2262
catherine.egan@moorfields.nhs.uk

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United States

California

Scripps Research Institute
La Jolla, CA USA
Martin Friedlander, MD, PhD
858-784-9138
friedlan@scripps.edu

Jules Stein Eye Institute, UCLA
Los Angeles, CA USA
Jean-Pierre Hubschman, MD
310-206-5004
hubschman@jsei.ucla.edu

Florida

Bascom Palmer Eye Institute, University of Miami
Miami, FL USA
Philip Rosenfeld, MD
305-326-6538
prosenfeld@med.miami.edu

Massachusetts

Massachusetts Eye and Ear Infirmary
Boston, MA USA
Joan Miller, MD
617-578-3257
joan.miller@meei.harvard.edu

Michigan

University of Michigan, Kellogg Eye Center
Ann Arbor, MI USA
Grant Comer, MD
734-763-5906
gcomer@umich.edu

New York

Manhattan Eye, Ear & Throat Hospital
New York, NY USA
Michael Cooney, MD
212 861-9797
m.cooney@vrmny.com

The New York Eye and Ear Infirmary
New York, NY USA
Richard Rosen, MD
212-979-4284
rrosen@nyee.edu

Ohio

Retina Associates of Cleveland, Inc.
Cleveland, OH USA
Lawrence Singerman, MD
216-831-5700
lsingerman@retina-assoc.com

Pennsylvania

Scheie Eye Institute
Philadelphia, PA USA
Alexander Brucker, MD
215-662-8675
ajbrucke@mail.med.upenn.edu

Utah

University of Utah Medical Center
Salt Lake City, Utah
Paul Bernstein, MD, PhD.
801-581-6078
paul.bernstein@hsc.utah.edu

Virginia

The Retina Group of Washington
Fairfax, VA USA
Robert Murphy, MD
703-698-9335
rpmurphy@comcast.net

Wisconsin

University of Wisconsin
Madison, WI USA
Barbara Blodi, MD
608-263-6646
bablodi@wisc.edu

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France

Hopital Lariboisiere
Paris, France
Alain Gaudric, MD
011 33 1 4995 2475
alain.gaudric@lrb.aphp.fr

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Germany

Universitats-Augenklinik Bonn
Bonn, Germany
Frank Holz, MD
011 49 228 287 5647
Frank.Holz@ukb.uni-bonn.de

St. Franziskus Hospital
Muenster, Germany
Prof. Daniel Pauleikhoff
dapauleikhoff@muenster.de
Bjorn Padge, MD
011 49-251-93308-0
bjoern@padge.de

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Israel

The Goldschleger Eye Institute
Tel Hashomer, Israel
Joseph Moisseiev, MD
011 972 3 5343462
Joseph.moisseiev@sheba.health.gov.il

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Switzerland

Klinik und Poliklinik fur Augenheilkunde
Inselspita
University of Bern
Bern, Switzerland
Sebastian Wolf, MD, PhD
41 31 6328503
sebastian.wolf@insel.ch

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Australia

Center for Eye Research Australia
Melbourne, Australia
Robyn Guymer, MD
011 61 3 9929 8393
rhg@unimelb.edu.au

Lions Eye Institute
Nedlands, Australia
Ian Constable, MD
011 61 8 9381 0882
ijc@cyllene.uwa.edu.au

Save Sight Institute
Sydney NSW Australia
Mark Gillies, MD, PhD
011 61 412 060 313
mark.gillies@sydney.edu.au

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