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About Macular Telangiectasia (MacTel)

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Macular Telangiectasia type 2 is a disease of the retina, the light-sensing tissue at the back of the eye. MacTel leads to a gradual deterioration of central vision, which becomes noticeable to people around 40 to 50 years of age.

The gradual loss of central vision people experience because of MacTel has a significant impact on quality of life. This is because central vision is required for tasks that require sharp vision, like reading and driving. In MacTel, the quality of a person’s central vision decreases over a period of 10 to 20 years, or more.

Macular Telangiectasia type 2 is a bilateral disease, which means that both eyes are affected. However, the disease does not necessarily affect both eyes equally. It may progress more quickly in one eye than the other. A person with MacTel may see more clearly with one eye than the other. The disease may become apparent earlier in one eye than the other.

MacTel may be an inherited disease. The MacTel Project has studied about 20 families with MacTel to determine the pattern of inheritance, and to look for responsible genes. Between 10-50% of an affected person’s first-degree relatives (parent, sibling, or child) may have MacTel. A “MacTel gene” has not yet been identified. In fact, multiple genes may be involved in the development of MacTel.

eye-anatomyMacular telangiectasia type 2 affects a well-defined area of the retina, which is referred to as the “MacTel zone.” This is an oval-shaped area centered on the fovea. The fovea is contained within the macula, the central area of the retina. The fovea is the focal point for light entering the eye. It is the region of the retina with the highest density of cone photoreceptor cells. Humans rely heavily on the fovea to construct a clear picture of their surroundings. In fact, about half of the nerve fibers traveling from the retina to the brain carry information from the fovea. In the course of MacTel, photoreceptors in and around the fovea die.

In the MacTel eyes that have been donated for research thus far, Müller cells were found to be missing from the MacTel Zone. Müller cells play an important supportive role to photoreceptors in the retina. The cause of their disappearance from the MacTel Zone in patients is still under investigation. We Changes in the retinal pigment epithelial cells (RPE), and their function, are also apparent in the course of the disease. Clinically, there is a readily observed change in the retina’s blood vessels; they become dilated and take on new patterns.

These physiological changes, and others, are the subject of LMRI research.

United Kingdom
Moorfields Eye Hospital

London, United Kingdom
Cathy Egan, MD

Emily Magnus
Tel: 020 7566 2117
Email:Emily.Magnus@moorfields.nhs.uk
 

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United States

California

Scripps Research Institute

La Jolla, CA USA
Martin Friedlander, MD, PhD

Jennifer Trombley, RN
Tel: 858-554-6678
Email: Trombley.jennifer@scrippshealth.org

Jules Stein Eye Institute, UCLA

Los Angeles, CA USA
Jean-Pierre Hubschman, MD

Veronika Sadykov
Tel: 310-794-5596
Email: Sadykov@jsei.ucla.edu

Mary Crowley
Tel: 310-267-5278 Email:
Email: MECrowley@mednet.ucla.edu

University of California – San Francisco

UCSF Department of Ophthalmology
San Fransciso, CA USA
Jacque Duncan, MD

Arshia Mian
Tel: 415-476-0444
Email: arshia.mian@ucsf.edu

Florida

Bascom Palmer Eye Institute, University of Miami

Miami, FL USA
Philip Rosenfeld, MD

Cristina Lage-Rodriguez
Tel: 305-326-6117
Email: clage@med.miami.edu

Georgia

Emory University

Atlanta, GA
Jiong Yan, MD

Jayne Brown
Tel: 404-778-4430
Email: jmbrown@emory.edu

Louisiana

Retina Associates New Orleans

New Orleans, LA USA
Stanislav A. Zhuk, MD

Corey Marvel
Tel: 504-456-9061 ext 1111
Email: cmarvel@retinaassociates.org

Melinda Mitchell
Email: Melinda.mitchell@retinaassociates.org

Massachusetts

Massachusetts Eye and Ear Infirmary

Boston, MA USA
Joan Miller, MD

Patricia Houlihan
Tel: 617-573-3646
Email: patricia_houlihan@meei.harvard.edu

Michigan

University of Michigan, Kellogg Eye Center

Ann Arbor, MI USA
Grant Comer, MD

Pam Campbell
Tel: 734-936-0138
Email: pamtitus@med.umich.edu

New York

Vitreous, Retina, Macula Consultants of New York

New York, NY USA
Lawrence A. Yannuzzi, MD

Renata Salgado
Tel: 212-452-6965
Email: rsalgado@vrmny.com

The New York Eye and Ear Infirmary

New York, NY USA
Richard Rosen, MD

Meliza Unson
Tel: 212-979-4672
Email: munson@nyee.edu

University of Rochester

Rochester, NY USA
Mina Chung, MD

Lisa Latchney
Tel: 585-273-2742
Email: Lisa_latchney@urmc.rochester.edu

Ohio

Retina Associates of Cleveland, Inc.

Cleveland, OH USA
Lawrence Singerman, MD

Diane Weiss
Tel: 216-831-5704 Ext. 244
Email: dew@retina-assoc.com

Cincinnati Eye Institute

Cincinnati, OH USA
Daniel Miller, MD

Megan Kingdon
Tel: 513-569-3669
Email: mkingdon@cincinnatieye.com

Pennsylvania

Scheie Eye Institute

Philadelphia, PA USA
Alexander Brucker, MD

Sheri Drossner
Tel: 215-662-8177
Email: Sheri.Grand@uphs.upenn.edu

Texas

Retina Research Center

Austin, TX USA
Chirag Jhaveri, MD
Brian Berger, MD

Ivana Gunderson
Tel: 512-279-1251
Email: igunderson@e-retina.net

Utah

University of Utah Medical Center

Salt Lake City, Utah
Paul Bernstein, MD, PhD.

Kara Halsey
Tel: 801-213-2034
Email: Kara.halsey@utah.edu

Virginia

The Retina Group of Washington

Fairfax, VA USA
Robert Murphy, MD

Irene Fanous
Tel: 703-564-7519
Email: ifanous@rgw.com

Wisconsin

Medical College of Wisconsin

Milwaukee, WI USA
David Weinberg, MD

Ellie Dorsey
Tel: 414-955-7854
Email: edorsey@mcw.edu
 

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France
Hopital Lariboisiere

Paris, France
Alain Gaudric, MD

Abir Zureik
Tel: 33 1 49 95 64 86
Email: abir.zureik@aphp.fr
 

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Germany
Universitats-Augenklinik Bonn

Bonn, Germany
Frank Holz, MD

Simone Müller
Email: Simone.Mueller@ukbonn.de

Kerstin Bartsch
Email: Kerstin.Bartsch@ukbonn.de

St. Franziskus Hospital

Muenster, Germany
Prof. Daniel Pauleikhoff

Elke Attenberger
Tel: 0251-9352758
Email: elke.attenberger@uveitis-zentrum.de
 

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Israel
The Goldschleger Eye Institute

Tel Hashomer, Israel
Joseph Moisseiev, MD

Rinat Rashty
Tel: 972-3-530 2877
Email: Rinat.rashty@sheba.health.gov.il

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Switzerland

Klinik und Poliklinik fur Augenheilkunde
Inselspita
University of Bern
Bern, Switzerland
Sebastian Wolf, MD, PhD
41 31 6328503
sebastian.wolf@insel.ch

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Australia
Center for Eye Research Australia

Melbourne, Australia
Robyn Guymer, MD

Melinda Cain
Tel: 61 3 9929 8396
Email: mcain@unimelb.edu.au

Emily Caruso
Tel: 61 3 9929 8113
Email: emily.caruso@unimelb.edu.au

Lions Eye Institute

Nedlands, Australia
Ian Constable, MD

Toni Busby
Tel: +61 08 6382 0582
Email: toni.busby@lei.org.au

Diana Bowman
Tel: +61 8 9381 0777
Email: DianaBowman@lei.org.au

Save Sight Institute

Sydney NSW Australia
Mark Gillies, MD, PhD

Antoinette Dezoysa
Tel +61 2 9382 7309
Email: Antoinette.dezoysa@sydney.edu.au

Sharon McKenzie
Tel +61 2 9382 7309
Email: sharon.mckenzie@sydney.edu.au

 
 

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Netherlands
Radboud University Medical Center

Nijmegen, Netherlands

CB Hoyng, MD
Tel: +31 (0)24 36 15255
Email: trialcentrum.ohk@radboudumc.nl

Asha Kalisingh
Tel: + 0243613212
Email: asha.kalisingh@radboudumc.nl
 

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