Moorfields Reading Center

The Moorfields Reading Centre evaluates all ophthalmic images collected as part of the MacTel Project Registry and the Natural History Observation Study, and offers the official diagnosis of MacTel for patients who participate in these research projects.

The Moorfields Reading Centre for ophthalmic images was established by the Moorfields Eye Hospital NHS Foundation Trust, in partnership with the University College London Institute of Ophthalmology.  The Moorfields Reading Centre was established because there was a recognized need for a center that could create robust ophthalmic surveys and clinical trial project designs.  Clinical trials were hampered by an inability to develop robust outcome measures, in part because ophthalmic diseases had not been thoroughly characterized.  The Reading Centre serves as an unbiased, independent center for image analysis.

The Reading Centre standardizes the definition of diseased states, relating to the retina.  They also standardize what is classified as an abnormality in ophthalmic images.  They collect measurements from images, and grade images, so that changes can be recognized.

The classification of disease status has been extremely important to the MacTel Project.  One aspect of the MacTel Project is to analyze families with macular telangiectasia type 2.  Following the identification of one individual in a family with MacTel (the “proband”), their relatives may be examined for MacTel.  The Moorfields Reading Centre determines if family members are affected or unaffected.   This can be difficult for an age-related disease, where it is possible that an individual is not yet showing all of the symptoms of disease that would lead to a definitive diagnosis.