CNTF Clinical Trials: COVID-19 Update

March 24, 2020 The rapid spread of COVID-19 has disrupted many standard clinical operations, including the LMRI/Neurotech Phase 1, 2, and 3 clinical trials testing CNTF in MacTel. If you have questions regarding upcoming appointments or other study-related questions and are having trouble reaching the study team, please use our contact page and we will assist… View Article

Phase 3 Trial Currently Enrolling MacTel Patients

In a collaboration with Neurotech Pharmaceuticals, the Lowy Medical Research Institute is currently enrolling a Phase 3 clinical trial testing ciliary neurotrophic factor (CNTF) in patients with macular telangiectasia type 2.  This is a multi-center trial, with clinical sites in the United States, Europe, and Australia. How do I Participate? You may contact a clinical site… View Article

The Latest MacTel Research: What does it mean for patients?

Scientists at the Lowy Medical Research Institute and their collaborators recently published an article describing a role for serine and toxic lipids in macular telangiectasia type 2.  The article, “Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy,” was published online by the New England Journal of Medicine on September 11, 2019.1 The findings… View Article

Lowy Medical Research Institute scientists find cause of debilitating eye disease

15-year effort points to treatments to help MacTel patients and offers potential new insights into other eye diseases LA JOLLA, CA–September 11, 2019– Scientists at the Lowy Medical Research Institute (LMRI) have discovered one cause of a progressive, debilitating eye disease called macular telangiectasia type 2 (MacTel). The work, using genetic, clinical and biochemical studies… View Article

Results of NT-501 Phase 2 Study Published

January 16, 2019, Cumberland, RI and La Jolla, CA. The results of the NT-501 Phase 2 study sponsored by Neurotech Pharmaceuticals, Inc. (Neurotech) in collaboration with the Lowy Medical Research Institute (LMRI), have been published in the journal of the American Academy of Ophthalmology, Ophthalmology1. The study, a Phase 2 multi-center randomized clinical trial, tested… View Article

2018 MacTel Project Annual Summary

The Lowy Medical Research Institute would like to announce the latest MacTel Project Newsletter, which contains important updates on the Natural History Observation and Registry (NHOR) Study, Clinical Trials, and MacTel Projects.

Neurotech Announces Positive Phase 2 Results in NT-501 (CNTF) for Macular Telangiectasia

Neurotech Pharmaceuticals, Inc., in collaboration with the Lowy Medical Research Institute (LMRI), today announced 24-month results demonstrating that NT-501 delivering Ciliary Neurotrophic Factor (CNTF) has a beneficial effect in patients with Macular Telangiectasia type 2 (MacTel). The multicenter, randomized clinical trial demonstrated a statistically significant reduction in the progressive loss of photoreceptors in treated versus untreated eyes. NT-501 utilizes the Company’s proprietary Encapsulated Cell Therapy (ECT) platform that can be customized to deliver specific therapeutic molecules to the back of the eye for retinal disease.

LMRI Scientists Selected to Participate in Biocom’s “Taking Art to the Cellular Level” Exhibit

Two scientists affiliated with the Lowy Medical Research Institute, Dr. Peter Westenskow and Dr. Michael Dorrell, were selected to participate in a public exhibit that showcased the artistic side of science. Dr. Westenskow exhibited an image of the architecture of the retina, taken by electron microscopy. The image was taken in collaboration with Dr. Malcom Wood at The Scripps Research Institute.

LMRI Affiliate John Dowling Receives Funding to Map Intercellular Connections in the Retina

The Lowy Medical Research Institute is helping to fund a study that will map intracellular connections in the retina.  The retina is composed of several different cell types, including neurons, glia, and blood vessels.  The retina has been studied at a sub-cellular level using electron microscopy, but these subcelluar snapshots do not provide a clear picture as to how the cells in the retina are interconnected.