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Self-Supervised Learning for Improved Optical Coherence Tomography Detection of Macular Telangiectasia Type 2

Gholami S, Scheppke L, Kshirsagar M, Wu Y, Dodhia R, Bonelli R, Leung I, Sallo FB, Muldrew A, Jamison C, Peto T, Lavista Ferres J, Weeks WB, Friedlander M, Lee AY; MacTel Research Group. Self-Supervised Learning for Improved Optical Coherence Tomography Detection of Macular Telangiectasia Type 2. JAMA Ophthalmol. 2024...

Retinal pigment epithelial cells reduce vascular leak and proliferation in retinal neovessels

Tzaridis S, Aguilar E, Dorrell MI, Friedlander M, Eade KT. Retinal pigment epithelial cells reduce vascular leak and proliferation in retinal neovessels. Angiogenesis. 2024 Nov 27;28(1):1. doi: 10.1007/s10456-024-09954-4. PMID: 39601967; PMCID: PMC11602807.

Developing a Continuous Severity Scale for Macular Telangiectasia Type 2 Using Deep Learning and Implications for Disease Grading

Wu Y, Egan C, Olvera-Barrios A, Scheppke L, Peto T, Charbel Issa P, Heeren TFC, Leung I, Rajesh AE, Tufail A, Lee CS, Chew EY, Friedlander M, Lee AY. Developing a Continuous Severity Scale for Macular Telangiectasia Type 2 Using Deep Learning and Implications for Disease Grading. Ophthalmology. 2024 Feb;131(2):219-226....

Imbalanced unfolded protein response signaling contributes to 1-deoxysphingolipid retinal toxicity

Rosarda JD, Giles S, Harkins-Perry S, Mills EA, Friedlander M, Wiseman RL, Eade KT. Imbalanced unfolded protein response signaling contributes to 1-deoxysphingolipid retinal toxicity. Nat Commun. 2023 Jul 11;14(1):4119. doi: 10.1038/s41467-023-39775-w. PMID: 37433773; PMCID: PMC10336013.

Divergent amino acid and sphingolipid metabolism in patients with inherited neuro-retinal disease

Green CR, Bonelli R, Ansell BRE, Tzaridis S, Handzlik MK, McGregor GH, Hart B, Trombley J, Reilly MM, Bernstein PS, Egan C, Fruttiger M, Wallace M, Bahlo M, Friedlander M, Metallo CM, Gantner ML. Divergent amino acid and sphingolipid metabolism in patients with inherited neuro-retinal disease. Mol Metab. 2023 Jun;72:101716....

Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery

Eade K, Giles S, Harkins-Perry S, Friedlander M. Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery. J Vis Exp. 2021 Mar 4;(169). doi: 10.3791/62269. PMID: 33749682.

Functional Relevance of Hyper-Reflectivity in Macular Telangiectasia Type 2

Tzaridis S, Friedlander M; Macular Telangiectasia Type 2-Phase 2 CNTF Research Group. Functional Relevance of Hyper-Reflectivity in Macular Telangiectasia Type 2. Invest Ophthalmol Vis Sci. 2021 Mar 1;62(3):6. doi: 10.1167/iovs.62.3.6. PMID: 33661283; PMCID: PMC7937992.

Optical coherence tomography-angiography for monitoring neovascularisations in macular telangiectasia type 2

Tzaridis S, Hess K, Friedlander M, Holz FG. Optical coherence tomography-angiography for monitoring neovascularisations in macular telangiectasia type 2. Br J Ophthalmol. 2021 May;105(5):735-740. doi: 10.1136/bjophthalmol-2020-316021. Epub 2020 Jun 8. PMID: 32513667.

Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder

Bonelli R, Jackson VE, Prasad A, Munro JE, Farashi S, Heeren TFC, Pontikos N, Scheppke L, Friedlander M; MacTel Consortium; Egan CA, Allikmets R, Ansell BRE, Bahlo M. Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder. Commun Biol. 2021 Mar 2;4(1):274. doi: 10.1038/s42003-021-01788-w....

Deep learning-based classification and segmentation of retinal cavitations on optical coherence tomography images of macular telangiectasia type 2

Loo J, Cai CX, Choong J, Chew EY, Friedlander M, Jaffe GJ, Farsiu S. Deep learning-based classification and segmentation of retinal cavitations on optical coherence tomography images of macular telangiectasia type 2. Br J Ophthalmol. 2022 Mar;106(3):396-402. doi: 10.1136/bjophthalmol-2020-317131. Epub 2020 Nov 23. PMID: 33229343; PMCID: PMC8365558.